Title : Safety and Efficacy of PTH 1-34 and 1-84 Therapy in Chronic Hypoparathyroidism: A Meta-Analysis of Prospective Trials.

Pub. Date : 2022 Apr 29

PMID : 35485213






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1 PTH therapy had a neutral effect on calcium levels, while lowering serum phosphate (-0.21 mmol/l; 95%CI:-0.31 to -0.11 mmol/l; p<0.001) and urinary calcium excretion (-1.21 mmol/24h; 95%CI:-2.03 to -0.41 mmol/24h; p=0.003). Calcium parathyroid hormone Homo sapiens
2 PTH therapy had a neutral effect on calcium levels, while lowering serum phosphate (-0.21 mmol/l; 95%CI:-0.31 to -0.11 mmol/l; p<0.001) and urinary calcium excretion (-1.21 mmol/24h; 95%CI:-2.03 to -0.41 mmol/24h; p=0.003). Calcium parathyroid hormone Homo sapiens
3 In conclusion, the meta-analysis of data from the largest collection to date of hypoparathyroid patients shows that PTH therapy is safe, well-tolerated and effective in normalizing serum phosphate and urinary calcium excretion, as well as enabling a reduction in calcium and vitamin D use and improving quality of life. Calcium parathyroid hormone Homo sapiens
4 In conclusion, the meta-analysis of data from the largest collection to date of hypoparathyroid patients shows that PTH therapy is safe, well-tolerated and effective in normalizing serum phosphate and urinary calcium excretion, as well as enabling a reduction in calcium and vitamin D use and improving quality of life. Calcium parathyroid hormone Homo sapiens