Pub. Date : 2022 Jun
PMID : 35483199
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | G9a inhibition by CM-272: Developing a novel anti-tumoral strategy for castration-resistant prostate cancer using 2D and 3D in vitro models. | CM-272 | euchromatic histone lysine methyltransferase 2 | Homo sapiens |
| 2 | We disclose that, under the evaluated dose, CM-272 led to G9a activity inhibition, while not significantly affecting DNMT1 activity. | CM-272 | euchromatic histone lysine methyltransferase 2 | Homo sapiens |
| 3 | Contrarily, PC3 cell viability impact was higher in G9a knockdown, compared with CM-272 treatment, suggesting an additional G9a function. | CM-272 | euchromatic histone lysine methyltransferase 2 | Homo sapiens |
| 4 | Moreover, DU145 cells overexpressing catalytically functional G9a disclosed higher resistance to CM-272 treatment, reinforcing that the drug mechanism of action is dependent on G9a catalytic function. | CM-272 | euchromatic histone lysine methyltransferase 2 | Homo sapiens |
| 5 | Moreover, DU145 cells overexpressing catalytically functional G9a disclosed higher resistance to CM-272 treatment, reinforcing that the drug mechanism of action is dependent on G9a catalytic function. | CM-272 | euchromatic histone lysine methyltransferase 2 | Homo sapiens |
| 6 | We concluded that inhibition of G9a methyltransferase activity by CM-272 has anti-tumor effect in PCa cells, holding therapeutic potential against CRPC. | CM-272 | euchromatic histone lysine methyltransferase 2 | Homo sapiens |