Title : The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin.

Pub. Date : 2022 Jun 1

PMID : 35483142






2 Functional Relationships(s)
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1 Eventually, pretreatment with NAC, an ROS inhibitor, alleviates citrinin-induced cell cycle G2/M arrest and apoptosis by inhibiting ROS-mediated ER stress; pretreatment with 4-PBA, an ER stress inhibitor, reversed ER stress and p-AMPK; pretreatment with dorsomorphin, an AMPK inhibitor, decreases citrinin-induced cell cycle G2/M arrest and apoptosis. Reactive Oxygen Species synuclein alpha Homo sapiens
2 Eventually, pretreatment with NAC, an ROS inhibitor, alleviates citrinin-induced cell cycle G2/M arrest and apoptosis by inhibiting ROS-mediated ER stress; pretreatment with 4-PBA, an ER stress inhibitor, reversed ER stress and p-AMPK; pretreatment with dorsomorphin, an AMPK inhibitor, decreases citrinin-induced cell cycle G2/M arrest and apoptosis. Reactive Oxygen Species synuclein alpha Homo sapiens