Pub. Date : 2022
PMID : 35463361
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lapatinib Suppresses HER2-Overexpressed Cholangiocarcinoma and Overcomes ABCB1- Mediated Gemcitabine Chemoresistance. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The synergistic effect of lapatinib and gemcitabine was interpreted by docking analysis, ABCB1-associated ATPase assay, rhodamine transport assay and LC-MS/MS analyses. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Lapatinib exerts a dual effect on HER2-overexpressed CCA, suppressing the growth of CCA cells by inhibiting HER2 and HER2-dependent downstream signaling pathways while inhibiting ABCB1 transporter function, allowing for the accumulation of active gemcitabine metabolites within cells. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Conclusions: Our data demonstrates that lapatinib can not only inhibit growth of CCA overexpressing HER2, but can also circumvent ABCB1-mediated chemoresistance after gemcitabine treatment. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |