Pub. Date : 2022 Jun
PMID : 35462331
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ABCB1 as a potential beneficial target of midostaurin in acute myeloid leukemia. | midostaurin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Midostaurin, identified as an ABCB1 inhibitor, increased anthracycline accumulation in peripheral blood mononuclear cells (PBMC) of CD34+ AML patients and those not achieving CR. | midostaurin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | In line with these data, midostaurin potentiated proapoptotic processes in ABCB1-overexpressing leukemic cells when combined with anthracyclines. | midostaurin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Overall, we highlight the therapeutic value of midostaurin as more than just a FLT3 inhibitor, suggesting its maximal therapeutic outcomes might be very sensitive to proper timing and well-optimized dosage schemes based upon patient"s characteristics, such as CD34 positivity and ABCB1 activity. | midostaurin | ATP binding cassette subfamily B member 1 | Homo sapiens |