Title : Activation of transcription factor HIF inhibits IL-1β-induced NO production in primary cultured rat hepatocytes.

Pub. Date : 2022 Jul 1

PMID : 35460897






2 Functional Relationships(s)
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1 RNA-Seq analysis of mRNA expression in rat hepatocytes showed that roxadustat treatment decreased the expression of genes related to inflammation, and genes in the NF-kappaB signaling pathway were induced by IL-1beta. roxadustat interleukin 1 alpha Rattus norvegicus
2 Moreover, roxadustat suppressed IL-1beta-activated signaling pathways in an HIF-dependent manner. roxadustat interleukin 1 alpha Rattus norvegicus