Title : Dexmedetomidine improved one-lung ventilation-induced cognitive dysfunction in rats.

Pub. Date : 2022 Apr 23

PMID : 35459107






1 Functional Relationships(s)
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1 RESULTS: Post-MV, compared with group OLV, group DEX showed increases in percentage of target quadrant time (P < 0.05), platform crossings (P < 0.05), a reduction in CERO2 (P < 0.05), and pERK1/2, pCREB, and Bcl-2 significantly increased (P < 0.01 or P < 0.05), while BAX significantly decreased (P < 0.01), besides, a less damaged synaptic structure was observed in group DEX. Dexmedetomidine BCL2, apoptosis regulator Rattus norvegicus