Title : Rosmarinus officinalis L. Leaf Extracts and Their Metabolites Inhibit the Aryl Hydrocarbon Receptor (AhR) Activation In Vitro and in Human Keratinocytes: Potential Impact on Inflammatory Skin Diseases and Skin Cancer.

Pub. Date : 2022 Apr 13

PMID : 35458697






4 Functional Relationships(s)
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1 Hence, it would be very important to identify natural compounds that could inhibit the AhR activation by ligands of microbial origin as 6-formylindolo(3,2-b)carbazole (FICZ), indirubin (IND) and pityriazepin (PZ) or the prototype ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins aryl hydrocarbon receptor Homo sapiens
2 Hence, it would be very important to identify natural compounds that could inhibit the AhR activation by ligands of microbial origin as 6-formylindolo(3,2-b)carbazole (FICZ), indirubin (IND) and pityriazepin (PZ) or the prototype ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polychlorinated Dibenzodioxins aryl hydrocarbon receptor Homo sapiens
3 All assayed ROE extracts showed similar dose-dependent activities with almost complete inhibition of AhR activation by TCDD at 100 ppm. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor Homo sapiens
4 ROEs inhibit AhR activation by TCDD and by the Malassezia metabolites FICZ, PZ, and IND. Polychlorinated Dibenzodioxins aryl hydrocarbon receptor Homo sapiens