Pub. Date : 2022 Apr 13
PMID : 35457136
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexmedetomidine-induced EGFR tyrosine and JNK phosphorylation were inhibited by rauwolscine, PP1, PP2, GM6001, and AG1478. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | Furthermore, dexmedetomidine-induced JNK phosphorylation reduced upon EGFR siRNA treatment. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | Therefore, these results suggested that the transactivation of EGFR associated with dexmedetomidine-induced contraction, mediated by the alpha-2 adrenoceptor, Src kinase, and matrix metalloproteinase, caused JNK phosphorylation and increased calcium levels. | Dexmedetomidine | mitogen-activated protein kinase 8 | Rattus norvegicus |