Title : Cylindromatosis drives synapse pruning and weakening by promoting macroautophagy through Akt-mTOR signaling.

Pub. Date : 2022 May

PMID : 35449295






2 Functional Relationships(s)
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1 Consequently, abrogating the Akt-mTOR-autophagy signaling pathway abolishes CYLD-induced spine loss, whereas enhancing autophagy in vivo by the mTOR inhibitor rapamycin rescues the synaptic pruning and LTD deficits in mutant mice. Sirolimus mechanistic target of rapamycin kinase Mus musculus
2 Consequently, abrogating the Akt-mTOR-autophagy signaling pathway abolishes CYLD-induced spine loss, whereas enhancing autophagy in vivo by the mTOR inhibitor rapamycin rescues the synaptic pruning and LTD deficits in mutant mice. Sirolimus mechanistic target of rapamycin kinase Mus musculus