Title : Oxidative stress generated by polycyclic aromatic hydrocarbons from ambient particulate matter enhance vascular smooth muscle cell migration through MMP upregulation and actin reorganization.

Pub. Date : 2022 Apr 22

PMID : 35449013






4 Functional Relationships(s)
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Protein Name
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1 The phosphorylated levels of focal adhesion kinase (FAK) and formation of the focal adhesion complex were significantly increased in ambient PM or PAH-treated VSMCs, and these effects were blocked by administration of NAC or alpha-NF, an inhibitor of AhR, the receptor that allows PAH uptake. Polycyclic Aromatic Hydrocarbons protein tyrosine kinase 2 Homo sapiens
2 The phosphorylated levels of focal adhesion kinase (FAK) and formation of the focal adhesion complex were significantly increased in ambient PM or PAH-treated VSMCs, and these effects were blocked by administration of NAC or alpha-NF, an inhibitor of AhR, the receptor that allows PAH uptake. Polycyclic Aromatic Hydrocarbons protein tyrosine kinase 2 Homo sapiens
3 The phosphorylated levels of focal adhesion kinase (FAK) and formation of the focal adhesion complex were significantly increased in ambient PM or PAH-treated VSMCs, and these effects were blocked by administration of NAC or alpha-NF, an inhibitor of AhR, the receptor that allows PAH uptake. Polycyclic Aromatic Hydrocarbons protein tyrosine kinase 2 Homo sapiens
4 The phosphorylated levels of focal adhesion kinase (FAK) and formation of the focal adhesion complex were significantly increased in ambient PM or PAH-treated VSMCs, and these effects were blocked by administration of NAC or alpha-NF, an inhibitor of AhR, the receptor that allows PAH uptake. Polycyclic Aromatic Hydrocarbons protein tyrosine kinase 2 Homo sapiens