Pub. Date : 2022
PMID : 35446876
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The mTOR inhibitor Rapamycin protects from premature cellular senescence early after experimental kidney transplantation. | Sirolimus | mechanistic target of rapamycin kinase | Rattus norvegicus |
| 2 | The mTOR inhibitor Rapamycin protects from senescence in experimental models, but its antiproliferative properties have raised concern early after transplantation particularly at higher doses. | Sirolimus | mechanistic target of rapamycin kinase | Rattus norvegicus |
| 3 | mTOR inhibition with low-dose Rapamycin in the immediate posttransplant period protected from premature cellular senescence without negative effects on structural and functional recovery from preservation/reperfusion damage, glucose homeostasis, and growth in a rat kidney transplantation model. | Sirolimus | mechanistic target of rapamycin kinase | Rattus norvegicus |