Title : The galloyl moiety enhances inhibitory activity of polyphenols against adipogenic differentiation in 3T3-L1 preadipocytes.

Pub. Date : 2022 May 10

PMID : 35441186






1 Functional Relationships(s)
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1 Our results showed that the existence of the galloyl moiety in the structure of polyphenols was necessary for their inhibition of adipogenic differentiation, which could help to delay cells from entering the G2/M phase as well as to hinder the MCE process in the early stage of differentiation and the downstream PPARgamma and C/EBPalpha related MAPK signaling pathway, probably via binding to IR and disturbing the alpha-helix in its conformation. Polyphenols peroxisome proliferator activated receptor gamma Homo sapiens