Title : Low Levels of Perfluorooctanoic Acid Exposure Activates Steroid Hormone Biosynthesis through Repressing Histone Methylation in Rats.

Pub. Date : 2022 May 3

PMID : 35438966






1 Functional Relationships(s)
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1 It was found that the serum levels of progesterone, testosterone, and estradiol were significantly increased after 0.015 and 0.15 mg/kg of PFOA exposure, and the expression of Star, a key rate-limiting gene, was up-regulated, while other steroidogenic genes Cyp11a1, Hsd3b, Cyp17a1, and Hsd17b were down-regulated. Testosterone hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 Rattus norvegicus