CPRiL

Protein Name	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Organism	Rattus norvegicus
Gene ID	24470
Gene Symbol	Hsd3b5
UniProt	P27364 (3BHS5_RAT)
Relationships	Total Number of functionally related compound(s) : 90 Total Number of Articles : 82
Description	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Gene Summary	Enables 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity and steroid binding activity. Involved in progesterone metabolic process; regulation of steroid biosynthetic process; and steroid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Jun 2025]
synonyms	NADPH-dependent 3-keto-steroid reductase Hsd3b5 3 beta-HSD III 3 beta-hydroxysteroid dehydrogenase 5 3 beta-hydroxysteroid dehydrogenase type 3 3 beta-hydroxysteroid dehydrogenase type 5 3 beta-hydroxysteroid dehydrogenase type 5-like 3 beta-hydroxysteroid dehydrogenase type III 3 beta-hydroxysteroid dehydrogenase type V 3-beta-HSD V 3-beta-hydroxy-5-ene steroid dehydrogenase NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase dihydrotestosterone 3-ketoreductase progesterone reductase steroid delta-isomerase, 3 beta Hsd1 Hsd3b RATHSDI Click to show/hide the synonyms
Properties