Title : Inhibition of miR-130b-3p restores autophagy and attenuates intervertebral disc degeneration through mediating ATG14 and PRKAA1.

Pub. Date : 2022 Jun

PMID : 35435532






2 Functional Relationships(s)
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1 Mechanistically, we confirmed that the miR-130b-3p regulated the ATG14 and PRKAA1 directly and the knockdown of the ATG14 or PRKAA1 as well as the treatment of autophagy inhibitor blockaded the autophagic flux and reversed the protective effects of miR-130b-3p inhibition in the TBHP-induced human NP cells. tert-Butylhydroperoxide protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens
2 Mechanistically, we confirmed that the miR-130b-3p regulated the ATG14 and PRKAA1 directly and the knockdown of the ATG14 or PRKAA1 as well as the treatment of autophagy inhibitor blockaded the autophagic flux and reversed the protective effects of miR-130b-3p inhibition in the TBHP-induced human NP cells. tert-Butylhydroperoxide protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens