Title : Metformin induces myeloma cells necrosis and apoptosis and it is considered for therapeutic use.

Pub. Date : 2022 Apr 15

PMID : 35427214






1 Functional Relationships(s)
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1 Western blotting analyses demonstrated that the apoptosis-related protein of cleaved caspase 3 was activated; the expressions of Mcl-1, IGF-1R, PI3K, pAKT, and pmTOR proteins were inhibited by metformin in H929, RPMI8226, and MM.1s cells. Metformin MCL1 apoptosis regulator, BCL2 family member Homo sapiens