Pub. Date : 2022 Jul
PMID : 35426132
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Impact of CYP2C9*11 Genetic Polymorphism on the Pharmacokinetics of Phenytoin and (S)-Warfarin. | Phenytoin | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | The objective of the current study was to characterize the in-vivo activity of CYP2C9 among carriers of CYP2C9*11, one of the "African" alleles and the fourth most common CYP2C9 variant allele among Caucasians by using two prototype substrates, phenytoin and (S)-warfarin. | Phenytoin | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | Among patients of African ancestry CYP2C9*11 genetic analysis should be considered prior to prescribing of narrow therapeutic window drugs such as phenytoin, warfarin, NSAIDs or siponimod. | Phenytoin | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |