Title : Synthesis of benzoin under supramolecular catalysis involving cyclodextrins in water: application for the preparation of the antiepileptic drug phenytoin.

Pub. Date : 2022 Mar 31

PMID : 35424977






3 Functional Relationships(s)
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1 Among the cyclodextrins screened for the synthesis of 2-hydroxy-1,2-diphenylethanone (benzoin) in water, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) exhibited the highest yield in the benzoin condensation reactions, and HP-beta-CD can be recycled several times with little loss of activity through the addition of fresh VB1. 2-Hydroxypropyl-beta-cyclodextrin ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens
2 Among the cyclodextrins screened for the synthesis of 2-hydroxy-1,2-diphenylethanone (benzoin) in water, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) exhibited the highest yield in the benzoin condensation reactions, and HP-beta-CD can be recycled several times with little loss of activity through the addition of fresh VB1. 2-Hydroxypropyl-beta-cyclodextrin ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens
3 Moreover, the complexation behaviors of HP-beta-CD with benzaldehyde and intermediates were studied by UV-vis and 2D-ROESY NMR spectroscopies to reveal the plausible mechanisms of the reactions, and HP-beta-CD did not act as a simple phase transfer agent. 2-Hydroxypropyl-beta-cyclodextrin ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens