Pub. Date : 2022 Apr 14
PMID : 35422087
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | SHMT2 deficiency promoted the accumulation of intracellular reactive oxygen species (ROS) by decreasing the NADH/NAD+, NADPH/NADP+, and GSH/GSSG ratios, leading to a loss in mitochondrial membrane potential, release of cytochrome c, translocation of Bcl-2 family protein and activation of caspase-3. | Reactive Oxygen Species | BCL2 apoptosis regulator | Homo sapiens |
2 | SHMT2 deficiency promoted the accumulation of intracellular reactive oxygen species (ROS) by decreasing the NADH/NAD+, NADPH/NADP+, and GSH/GSSG ratios, leading to a loss in mitochondrial membrane potential, release of cytochrome c, translocation of Bcl-2 family protein and activation of caspase-3. | Reactive Oxygen Species | BCL2 apoptosis regulator | Homo sapiens |