Pub. Date : 2022
PMID : 35419167
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of LRP6 with HLY78 Attenuates Oxidative Stress and Neuronal Apoptosis via GSK3beta/Sirt1/PGC-1alpha Pathway after ICH. | 4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine | glycogen synthase kinase 3 alpha | Mus musculus |
| 2 | HLY78 significantly improved the short- and long-term neurobehavioral deficits after ICH, which was accompanied with decreased oxidative stress and neuronal apoptosis, as well as increased expression of p-GSK3beta, Sirt1, and PGC-1alpha, as well as downregulation of Romo-1 and C-Caspase-3. | 4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine | glycogen synthase kinase 3 alpha | Mus musculus |
| 3 | Conclusion: Our results suggest that administration of HLY78 attenuated oxidative stress, neuronal apoptosis, and neurobehavioral impairments through the LRP6/GSK3beta/Sirt1/PGC-1alpha signaling pathway after ICH. | 4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine | glycogen synthase kinase 3 alpha | Mus musculus |