Pub. Date : 2022 May 20
PMID : 35417135
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, efforts to develop LXR agonists to reduce cardiovascular diseases have failed due to poor clinical outcomes-associated increased hepatic lipogenesis and elevated low-density lipoprotein (LDL) cholesterol (C). | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 2 | Here, we report that LXR inverse agonists are effective in lowering plasma LDL cholesterol and triglycerides in several models of hyperlipidemia, including the Ldlr null mouse model of atherosclerosis. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |
| 3 | Oral administration of a gut-specific LXR inverse agonist leads to reduction of Soat2 expression in the intestine and effectively lowers circulating LDL cholesterol and triglyceride levels without modulating LXR target genes in the periphery. | Cholesterol | nuclear receptor subfamily 1, group H, member 3 | Mus musculus |