Title : SIRT1 activity orchestrates ECM expression during hESC-chondrogenic differentiation.

Pub. Date : 2022 May

PMID : 35416346






1 Functional Relationships(s)
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1 Unexpectedly, when SIRT1 was activated, while ACAN was enhanced, glycosaminoglycans (GAGs) were reduced, paralleled by down regulation of gene expression for N-acetylgalactosaminyltransferase type 1 (GALNT1) responsible for GAG chain initiation/elongation. Glycosaminoglycans aggrecan Homo sapiens