Title : NAMPT-dependent NAD+ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress.

Pub. Date : 2022 Apr 11

PMID : 35410407






3 Functional Relationships(s)
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1 Under both weak and strong H2O2 stimulation, intracellular nicotinamide adenine dinucleotide (NAD+) was depleted to a similar extent by poly (ADP-ribose) (PAR) polymerase 1 (PARP1)-dependent consumption. NAD poly(ADP-ribose) polymerase 1 Homo sapiens
2 Under both weak and strong H2O2 stimulation, intracellular nicotinamide adenine dinucleotide (NAD+) was depleted to a similar extent by poly (ADP-ribose) (PAR) polymerase 1 (PARP1)-dependent consumption. NAD poly(ADP-ribose) polymerase 1 Homo sapiens
3 Collectively, these findings suggest that NAD+ dynamics balanced by PARP1-dependent consumption and NAMPT-dependent production are important to determine the form of cell death activated under oxidative stress. NAD poly(ADP-ribose) polymerase 1 Homo sapiens