Title : Potential Effects of Ibuprofen, Remdesivir and Omeprazole on Dexamethasone Metabolism in Control Sprague Dawley Male Rat Liver Microsomes (Drugs Often Used Together Alongside COVID-19 Treatment).

Pub. Date : 2022 Mar 30

PMID : 35408639






1 Functional Relationships(s)
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1 The results showed that ibuprofen acts as a non-competitive inhibitor for CYP3A2 activity with Ki = 224.981 +- 1.854 microM and IC50 = 230.552 +- 2.020 microM, although remdesivir showed a mixed inhibition pattern with a Ki = 22.504 +- 0.008 microM and IC50 = 45.007 +- 0.016 microM. remdesivir cytochrome P450, family 3, subfamily a, polypeptide 2 Rattus norvegicus