Title : TSPO Ligands Protect against Neuronal Damage Mediated by LPS-Induced BV-2 Microglia Activation.

Pub. Date : 2022

PMID : 35401924






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 And the NLRP3 inflammasome was increased in LPS-activated BV-2 microglia cells in the microglia-neuron coculture system; pretreatment with PK11195 and Midazolam limited this undesirable situation. Midazolam NLR family, pyrin domain containing 3 Mus musculus
2 Taken together, TSPO ligands PK11195 and Midazolam showed neuroprotective effects by reducing the inflammatory response of LPS-activated microglia, which may be related to the enhancement of mitophagy and the inhibition of NLRP3 inflammasome. Midazolam NLR family, pyrin domain containing 3 Mus musculus