Title : The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins.

Pub. Date : 2022 May

PMID : 35398355






2 Functional Relationships(s)
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1 The mouse nicotinamide mononucleotide adenylyltransferase (NMNAT) chaperones diverse pathological amyloid client proteins. Nicotinamide Mononucleotide nicotinamide nucleotide adenylyltransferase 1 Mus musculus
2 In this work, we identified that the NAD+ synthase - nicotinamide mononucleotide adenylyltransferase (NMNAT) 3 from mouse (mN3) exhibits potent chaperone activity to antagonize aggregation of a wide spectrum of pathological amyloid client proteins including alpha-synuclein, Tau (K19), amyloid-beta, and islet amyloid polypeptide. Nicotinamide Mononucleotide nicotinamide nucleotide adenylyltransferase 1 Mus musculus