Protein Name nicotinamide nucleotide adenylyltransferase 1
Organism Mus musculus
Gene ID 66454
Gene Symbol

Nmnat1

UniProt Q9EPA7 (NMNA1_MOUSE), Q3V449 (Q3V449_MOUSE)
Relationships Total Number of functionally related compound(s) : 20
Total Number of Articles : 48
Description

nicotinamide nucleotide adenylyltransferase 1

Gene Summary

Enables nicotinamide-nucleotide adenylyltransferase activity and nicotinate-nucleotide adenylyltransferase activity. Involved in negative regulation of neuron death. Acts upstream of or within NAD biosynthetic process and response to wounding. Located in nucleus. Used to study Leber congenital amaurosis 9 and retinal degeneration. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 9 and spondyloepiphyseal dysplasia, sensorineural hearing loss, intellectual developmental disorder, and Leber congenital amaurosis. Orthologous to human NMNAT1 (nicotinamide nucleotide adenylyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
  • NMN adenylyltransferase 1
  • NMN/NaMN adenylyltransferase 1
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Properties