Pub. Date : 2022 Apr 10
PMID : 35397768
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To develop a population pharmacokinetic model for midazolam in adult intensive care unit patients infected with COVID-19 and to assess the effect of inflammation, reflected by IL-6, on the pharmacokinetics of midazolam. | Midazolam | interleukin 6 | Homo sapiens |
| 2 | Midazolam clearance was reduced by increased IL-6 and IL-6 explained more of the variability within our patients than CRP. | Midazolam | interleukin 6 | Homo sapiens |
| 3 | Midazolam clearance was reduced by increased IL-6 and IL-6 explained more of the variability within our patients than CRP. | Midazolam | interleukin 6 | Homo sapiens |
| 4 | The midazolam clearance was reduced by 24% (6.7-5.1 L/h) when IL-6 increases from population median 116 to 300 pg/mL. | Midazolam | interleukin 6 | Homo sapiens |
| 5 | CONCLUSIONS: Inflammation, reflected by high IL-6, reduces midazolam clearance in critically ill patients with COVID-19. | Midazolam | interleukin 6 | Homo sapiens |