Title : Ultrasound-triggered reactive oxygen species effector nanoamplifier for enhanced combination therapy of mutant p53 tumors.

Pub. Date : 2022 Jul

PMID : 35395477






5 Functional Relationships(s)
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1 Ultrasound-triggered reactive oxygen species effector nanoamplifier for enhanced combination therapy of mutant p53 tumors. Reactive Oxygen Species tumor protein p53 Homo sapiens
2 In this study, we built an ultrasound-triggered ROS damage nanoamplifier using a synergistic strategy consisting of ROS damage and decreased tumor self-protection capability to enhance the treatment efficacy of mutant p53 tumors. Reactive Oxygen Species tumor protein p53 Homo sapiens
3 In this study, we built an ultrasound-triggered ROS damage nanoamplifier using a synergistic strategy consisting of ROS damage and decreased tumor self-protection capability to enhance the treatment efficacy of mutant p53 tumors. Reactive Oxygen Species tumor protein p53 Homo sapiens
4 In addition, TH287 allies with ROS to eliminate the mutated p53 protein in tumor cells, thus reducing the self-protective capacity of tumor cells. Reactive Oxygen Species tumor protein p53 Homo sapiens
5 The construction of a ROS nanoamplifier not only provides an effective strategy for the treatment of mutant p53 tumors but also supplies an integrated platform for tumor diagnosis and therapy. Reactive Oxygen Species tumor protein p53 Homo sapiens