Pub. Date : 2022
PMID : 35387349
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin Promotes Differentiation and Attenuates H2O2-Induced Oxidative Damage of Osteoblasts via the PI3K/AKT/Nrf2/HO-1 Pathway. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The PI3K/AKT signaling pathway was revealed to play an essential role in the metformin-induced osteogenic process, as shown by RNA sequencing. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | We added LY294002 to inhibit the PI3K/AKT pathway, and the results indicated that the osteogenic effect of metformin was also blocked. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Antioxidative Nrf2/HO-1 pathway, regarded as the downstream of PI3K/AKT pathway, was modulated by metformin in the protective process. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | In conclusion, our study revealed that metformin promoted osteogenic differentiation and H2O2-induced oxidative damage of osteoblasts via the PI3K/AKT/Nrf2/HO-1 pathway. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |