PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35387349-0	2022	Metformin Promotes Differentiation and Attenuates H2O2-Induced Oxidative Damage of Osteoblasts via the PI3K/AKT/Nrf2/HO-1 Pathway.	Metformin	0-9	AKT serine/threonine kinase 1	Homo sapiens	108-111	
35387349-5	2022	The PI3K/AKT signaling pathway was revealed to play an essential role in the metformin-induced osteogenic process, as shown by RNA sequencing.	Metformin	77-86	AKT serine/threonine kinase 1	Homo sapiens	9-12	
35387349-6	2022	We added LY294002 to inhibit the PI3K/AKT pathway, and the results indicated that the osteogenic effect of metformin was also blocked.	Metformin	107-116	AKT serine/threonine kinase 1	Homo sapiens	38-41	
35387349-9	2022	Antioxidative Nrf2/HO-1 pathway, regarded as the downstream of PI3K/AKT pathway, was modulated by metformin in the protective process.	Metformin	98-107	AKT serine/threonine kinase 1	Homo sapiens	68-71	
35387349-11	2022	In conclusion, our study revealed that metformin promoted osteogenic differentiation and H2O2-induced oxidative damage of osteoblasts via the PI3K/AKT/Nrf2/HO-1 pathway.	Metformin	39-48	AKT serine/threonine kinase 1	Homo sapiens	147-150