Pub. Date : 2022 Apr 13
PMID : 35377153
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The finding that quercetin-3-rutinoside inhibits protein disulfide isomerase (PDI) and potently blocks thrombosis in vivo has enabled the evaluation of PDI inhibition in multiple animal models of thrombus formation and has prompted clinical studies of PDI inhibition in thrombosis. | Rutin | prolyl 4-hydroxylase subunit beta | Homo sapiens |
| 2 | The finding that quercetin-3-rutinoside inhibits protein disulfide isomerase (PDI) and potently blocks thrombosis in vivo has enabled the evaluation of PDI inhibition in multiple animal models of thrombus formation and has prompted clinical studies of PDI inhibition in thrombosis. | Rutin | prolyl 4-hydroxylase subunit beta | Homo sapiens |
| 3 | Nonetheless, how quercetin-3-rutinoside blocks PDI activity remains an unanswered question. | Rutin | prolyl 4-hydroxylase subunit beta | Homo sapiens |
| 4 | Combining NMR spectroscopy, site-directed mutagenesis, and biological assays, we identified H256 as the key residue for PDI interacting with quercetin-3-rutinoside. | Rutin | prolyl 4-hydroxylase subunit beta | Homo sapiens |
| 5 | Quercetin-3-rutinoside inhibited the activity of PDI (WT) but not PDI (H256A). | Rutin | prolyl 4-hydroxylase subunit beta | Homo sapiens |
| 6 | Among several quercetin-3-rutinoside analogues tested, only compounds with a phenoxyl group at position 7 showed direct binding to PDI, further supporting our molecular model. | Rutin | prolyl 4-hydroxylase subunit beta | Homo sapiens |
| 7 | Studies using purified coagulation factors showed that quercetin-3-rutinoside inhibited the augmenting effects of PDI (WT), but not PDI (H256A), on tissue factor (TF) activity. | Rutin | prolyl 4-hydroxylase subunit beta | Homo sapiens |
| 8 | Together, our studies show that residue H256 in PDI and the phenoxyl group at position 7 in quercetin-3-rutinoside are essential for inhibition of PDI by quercetin-3-rutinoside. | Rutin | prolyl 4-hydroxylase subunit beta | Homo sapiens |
| 9 | Together, our studies show that residue H256 in PDI and the phenoxyl group at position 7 in quercetin-3-rutinoside are essential for inhibition of PDI by quercetin-3-rutinoside. | Rutin | prolyl 4-hydroxylase subunit beta | Homo sapiens |
| 10 | Together, our studies show that residue H256 in PDI and the phenoxyl group at position 7 in quercetin-3-rutinoside are essential for inhibition of PDI by quercetin-3-rutinoside. | Rutin | prolyl 4-hydroxylase subunit beta | Homo sapiens |