| Protein Name | prolyl 4-hydroxylase subunit beta |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5034 |
| Gene Symbol | P4HB |
| UniProt | P07237 (PDIA1_HUMAN), A0A024R8S5 (A0A024R8S5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
523
Total Number of Articles : 672 |
Description |
prolyl 4-hydroxylase subunit beta |
| Gene Summary |
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008] |
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| Properties | |