Title : ROS-responsive nanoparticles for oral delivery of luteolin and targeted therapy of ulcerative colitis by regulating pathological microenvironment.

Pub. Date : 2022 Mar

PMID : 35372817






1 Functional Relationships(s)
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1 In a dextran sulfate sodium-induced acute colitis murine model, LUT@TPGS-PBTE NPs alleviated body weight loss, colon length shortening, and damage to the colonic tissues due to the suppression of ROS and proinflammatory cytokines (e.g., IL-17A, IL-6, interferon-gamma, tumor necrosis factor-alpha), as well as upregulation of glutathione and anti-inflammatory factors (e.g., IL-10, IL-4). Dextran Sulfate interleukin 6 Mus musculus