Title : Ginkgolide A alleviates cardiac remodeling in mice with myocardial infarction via binding to matrix metalloproteinase-9 to attenuate inflammation.

Pub. Date : 2022 May 15

PMID : 35367419






4 Functional Relationships(s)
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1 This study aims to explore whether ginkgolide A (GA) could improve cardiac dysfunction of MI mice, and whether it could alleviate cardiac remodeling via binding to matrix metalloproteinase-9 (MMP9) to attenuate inflammation. ginkgolide A matrix metallopeptidase 9 Mus musculus
2 This study aims to explore whether ginkgolide A (GA) could improve cardiac dysfunction of MI mice, and whether it could alleviate cardiac remodeling via binding to matrix metalloproteinase-9 (MMP9) to attenuate inflammation. ginkgolide A matrix metallopeptidase 9 Mus musculus
3 The regulatory role of GA in downregulating Col I, Col III, fibronectin in NRCFs, and enhancing levels of ANP, BNP and beta-MHC in NRCMs were reversed by MMP9 overexpression, so as the downregulation of IL-1beta, IL-6 and TNF-alpha in Ang II-induced NRCFs and NRCMs. ginkgolide A matrix metallopeptidase 9 Mus musculus
4 GA could alleviate cardiac dysfunction and remodeling via binding to MMP9 to attenuate inflammation. ginkgolide A matrix metallopeptidase 9 Mus musculus