Protein Name matrix metallopeptidase 9
Organism Mus musculus
Gene ID 17395
Gene Symbol

Mmp9

UniProt P41245 (MMP9_MOUSE)
Relationships Total Number of functionally related compound(s) : 1156
Total Number of Articles : 1589
Description

matrix metallopeptidase 9

Gene Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016]

synonyms
  • matrix metalloproteinase-9
  • 92 kDa gelatinase
  • 92 kDa type IV collagenase
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Properties