Title : Tankyrase represses autoinflammation through the attenuation of TLR2 signaling.

Pub. Date : 2022 Apr 1

PMID : 35362478






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We provide mechanistic evidence that tankyrase deficiency resulted in tyrosine phosphorylation and activation of TLR2 and show that phosphorylation of tyrosine 647 within the TIR domain by SRC and SYK kinases was critical for TLR2 stabilization and signaling. Tyrosine Rous sarcoma oncogene Mus musculus
2 We provide mechanistic evidence that tankyrase deficiency resulted in tyrosine phosphorylation and activation of TLR2 and show that phosphorylation of tyrosine 647 within the TIR domain by SRC and SYK kinases was critical for TLR2 stabilization and signaling. Tyrosine Rous sarcoma oncogene Mus musculus