Title : miR-122 and the WNT/β-catenin pathway inhibit effects of both interleukin-1β and tumor necrosis factor-α in articular chondrocytes in vitro.

Pub. Date : 2022 Jun

PMID : 35362116






6 Functional Relationships(s)
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1 microRNA (miR) miR-122 represses these effects whereas miR-451 exacerbates IL-1beta-stimulated matrix metalloproteinase-13 (MMP-13) and prostaglandin E2 (PGE2) production. Dinoprostone interleukin 1 alpha Rattus norvegicus
2 microRNA (miR) miR-122 represses these effects whereas miR-451 exacerbates IL-1beta-stimulated matrix metalloproteinase-13 (MMP-13) and prostaglandin E2 (PGE2) production. Dinoprostone interleukin 1 alpha Rattus norvegicus
3 Both IL-1beta and TNF-alpha-stimulation increased MMP-13 and PGE2 production. Dinoprostone interleukin 1 alpha Rattus norvegicus
4 LiCl reduced IL-1beta-stimulated increases in MMP-13 and PGE2. Dinoprostone interleukin 1 alpha Rattus norvegicus
5 XAV and PKF increased IL-1beta-stimulated increases in MMP-13 and PGE2. Dinoprostone interleukin 1 alpha Rattus norvegicus
6 In this in vitro OA model, miR-122 protects against both IL-1beta and TNF-alpha stimulated increases in MMP-13 and PGE2 production. Dinoprostone interleukin 1 alpha Rattus norvegicus