Pub. Date : 2022 Mar-Apr
PMID : 35361667
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We examined postnatal CB1R expression in the major striatonigral circuit from striosomes of the striatum to the dopamine-containing neurons of the substantia nigra. | Dopamine | cannabinoid receptor 1 (brain) | Mus musculus |
| 2 | Our finding that CB1R plays a major role in postnatal wiring of the striatonigral dopamine-control system, with lasting consequences at least in mice, points to a crucial need to determine whether lactating mothers" use of CB1R agonists (e.g., in marijuana) or antagonists (e.g., type 2 diabetes therapies) can disrupt brain development in nursing offspring.Significance StatementWe report the surprising finding that cannabinoid receptor 1 (CB1R), which mediates the psychoactive effects of marijuana, is required for normal postnatal development of midbrain dopamine-containing neurons and their striatal inputs in mice. | Dopamine | cannabinoid receptor 1 (brain) | Mus musculus |
| 3 | Our finding that CB1R plays a major role in postnatal wiring of the striatonigral dopamine-control system, with lasting consequences at least in mice, points to a crucial need to determine whether lactating mothers" use of CB1R agonists (e.g., in marijuana) or antagonists (e.g., type 2 diabetes therapies) can disrupt brain development in nursing offspring.Significance StatementWe report the surprising finding that cannabinoid receptor 1 (CB1R), which mediates the psychoactive effects of marijuana, is required for normal postnatal development of midbrain dopamine-containing neurons and their striatal inputs in mice. | Dopamine | cannabinoid receptor 1 (brain) | Mus musculus |
| 4 | Mice with a mutation in the gene that encodes CB1R show abnormal striatonigral connections and displaced dopamine neurons indicating a postnatal function for CB1R in brain development. | Dopamine | cannabinoid receptor 1 (brain) | Mus musculus |
| 5 | Mice with a mutation in the gene that encodes CB1R show abnormal striatonigral connections and displaced dopamine neurons indicating a postnatal function for CB1R in brain development. | Dopamine | cannabinoid receptor 1 (brain) | Mus musculus |