Title : Oral Lisinopril Raises Tissue Levels of ACE2, the SARS-CoV-2 Receptor, in Healthy Male and Female Mice.

Pub. Date : 2022

PMID : 35359831






4 Functional Relationships(s)
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1 Oral Lisinopril Raises Tissue Levels of ACE2, the SARS-CoV-2 Receptor, in Healthy Male and Female Mice. Lisinopril angiotensin converting enzyme 2 Homo sapiens
2 However, it is unclear whether ACE1 inhibitors (e.g., lisinopril) or angiotensin receptor blockers (e.g., losartan) alter tissue ACE2 expression. Lisinopril angiotensin converting enzyme 2 Homo sapiens
3 Oral lisinopril increases ACE2, the cellular receptor for SARS-CoV-2, in tissues that are relevant to the transmission and pathogenesis of COVID-19. Lisinopril angiotensin converting enzyme 2 Homo sapiens
4 Remarkably, the addition of losartan prevented lisinopril-induced increases in ACE2 across tissues. Lisinopril angiotensin converting enzyme 2 Homo sapiens