Pub. Date : 2022
PMID : 35355868
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of ACSL4-Catalyzed Lipid Peroxidation Process Resists Cisplatin Ototoxicity. | Cisplatin | acyl-CoA synthetase long chain family member 4 | Homo sapiens |
| 2 | Our study aimed to investigate the effect of ACSL4-catalyzed lipid peroxidation on cisplatin-induced hearing loss and its possible protective mechanisms. | Cisplatin | acyl-CoA synthetase long chain family member 4 | Homo sapiens |
| 3 | Further, we reduced the level of lipid peroxide in hair cells by specifically inhibiting the expression of ACSL4, which protected hair cells from cisplatin damage at source. | Cisplatin | acyl-CoA synthetase long chain family member 4 | Homo sapiens |
| 4 | In conclusion, the lipid peroxidation process regulated by ACSL4 may be an important factor contributing to the sensitivity of hair cells to cisplatin. | Cisplatin | acyl-CoA synthetase long chain family member 4 | Homo sapiens |
| 5 | Inhibition of ACSL4 expression may be an effective preventive measure against cisplatin ototoxicity. | Cisplatin | acyl-CoA synthetase long chain family member 4 | Homo sapiens |