Title : Topical Administration of 0.3% Tofacitinib Suppresses M1 Macrophage Polarization and Allograft Corneal Rejection by Blocking STAT1 Activation in the Rat Cornea.

Pub. Date : 2022 Mar 2

PMID : 35353151






1 Functional Relationships(s)
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1 Tofacitinib reduced the mRNA expression of inflammatory cytokines, including iNOS, MCP-1, TNF-alpha, IL-6, IL-1beta, and VEGF-C, and inhibited STAT1 activation in rat corneal grafts. tofacitinib tumor necrosis factor Rattus norvegicus