Pub. Date : 2022 Jun 1
PMID : 35341775
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin alleviates dexamethasone-induced apoptosis by regulating autophagy via AMPK/mTOR/p70S6K in osteoblasts. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Treatment with the autophagy inhibitor 3-methyladenine (3-MA) attenuated the effect of metformin on apoptosis, autophagy, and the AMPK/mTOR/p70S6K signaling pathway. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Furthermore, sh-AMPK transfection and the mTOR activator MHY1485 impaired metformin-mediated inhibition of osteoblast apoptosis and promotion of autophagy. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | The AMPK/mTOR/p70S6K signaling pathway plays a role in metformin-mediated apoptosis suppression and autophagy promotion. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | In conclusion, metformin can alleviate Dex-induced osteoblast apoptosis by inducing autophagy via the AMPK/mTOR/p70S6K pathway. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |