Pub. Date : 2022 May
PMID : 35339025
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVES: Ribavirin inhibits eukaryotic translation initiation factor 4E (eIF4E), thereby decreasing cap-dependent translation. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 2 | OBJECTIVES: Ribavirin inhibits eukaryotic translation initiation factor 4E (eIF4E), thereby decreasing cap-dependent translation. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 3 | METHODS: In the pharmacodynamic study, ribavirin (400 mg BID for 14 days) was evaluated in 8 patients with HPV-positive localized oropharyngeal carcinoma with phosphorylated-eIF4E (p-eIF4E) >= 30%. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 4 | METHODS: In the pharmacodynamic study, ribavirin (400 mg BID for 14 days) was evaluated in 8 patients with HPV-positive localized oropharyngeal carcinoma with phosphorylated-eIF4E (p-eIF4E) >= 30%. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 5 | RESULTS: Six patients were evaluable in the pharmacodynamic study: 4 had decreased p-eIF4E after 14 days of ribavirin. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 6 | CONCLUSION: Oral ribavirin decreases p-eIF4E levels and is well-tolerated. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |