Title : NAD+ centric mechanisms and molecular determinants of skeletal muscle disease and aging.

Pub. Date : 2022 Jun

PMID : 35334034






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1 This review provides detailed insights into the roles of NAD+ along with molecular mechanisms during aging and disease conditions, such as the impacts of age-related NAD+ deficiencies on NAD+-dependent enzymes, including poly (ADP-ribose) polymerase (PARPs), CD38, and sirtuins within skeletal muscle, and the most recent studies on the potential of nutritional supplementation and distinct modes of exercise to replenish the NAD+ pool. NAD poly (ADP-ribose) polymerase family, member 1 Mus musculus