Title : Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo.

Pub. Date : 2022 Mar 18

PMID : 35327661






5 Functional Relationships(s)
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1 The abundance of nAbs against alphaSyn is altered in patients with PD. nabs synuclein alpha Homo sapiens
2 In this work, we biophysically characterized nAbs against alphaSyn (nAbs-alphaSyn) and determined their biological effects. nabs synuclein alpha Homo sapiens
3 Specific binding of nAbs-alphaSyn to monomeric alphaSyn was demonstrated by Dot blot, ELISA, and Surface Plasmon Resonance. nabs synuclein alpha Homo sapiens
4 The results demonstrate that serum of healthy individuals contains nAbs that specifically bind alphaSyn and inhibit aggregation of alphaSyn in vitro. nabs synuclein alpha Homo sapiens
5 The results demonstrate that serum of healthy individuals contains nAbs that specifically bind alphaSyn and inhibit aggregation of alphaSyn in vitro. nabs synuclein alpha Homo sapiens