Title : Local temporal Rac1-GTP nadirs and peaks restrict cell protrusions and retractions.

Pub. Date : 2022 Mar 25

PMID : 35319996






3 Functional Relationships(s)
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1 Spatiotemporal coordination of Rac1 and RhoA GTP-binding activities initiates and reinforces protrusions and retractions, but the control of their finite lifetime remains unclear. Guanosine Triphosphate ras homolog family member A Homo sapiens
2 We examined the relations of Rac1 and RhoA GTP-binding levels to key protrusion and retraction events, as well as to cell-ECM traction forces at physiologically relevant ECM stiffness. Guanosine Triphosphate ras homolog family member A Homo sapiens
3 High RhoA-GTP preceded retractions and Rac1-GTP elevation before protrusions. Guanosine Triphosphate ras homolog family member A Homo sapiens