Title : The C-glucosyl flavone isoorientin pretreatment attenuates the methylglyoxal-induced mitochondrial dysfunction in the human neuroblastoma SH-SY5Y cells: role for the AMPK-PI3K/Akt/Nrf2/γ-GCL/GSH axis.

Pub. Date : 2022 Mar 22

PMID : 35316449






2 Functional Relationships(s)
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1 Moreover, silencing of Nrf2 blocked the ISO-dependent gamma-GCL and GSH upregulation and the effects on the mitochondria of the MG-challenged cells. Pyruvaldehyde NFE2 like bZIP transcription factor 2 Homo sapiens
2 Then, ISO caused mitochondrial protection by an AMPK-PI3K/Akt/Nrf2/gamma-GCL/GSH-dependent manner in MG-administrated SH-SY5Y cells. Pyruvaldehyde NFE2 like bZIP transcription factor 2 Homo sapiens