Title : An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif.

Pub. Date : 2022 May

PMID : 35307397






1 Functional Relationships(s)
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1 To understand how LPL binds ANGPTL3/8 and ApoA5 blocks this interaction, we used hydrogen-deuterium exchange mass-spectrometry (HDXMS) and molecular modeling to map binding sites of LPL and ApoA5 on ANGPTL3/8. Deuterium angiopoietin like 3 Homo sapiens